Ints :

• 17a-hydroxy progesterone
• 16,17a-epoxy progesterone
• 6-methyl-16,17a-epoxy progesterone

Medroxyprogesterone acetate is derived from the progesterone which is the main hormone involved in the pregnancy. Progesterone helps the womb to accept the fertilized egg as well as maintaining the growth of the fetus. Progesterone regulates other hormones to start and stop the menstrual cycle. Medroxyprogesterone is given to treat premenstrual syndrome (PMS), absence of menstruation, prevent premature labor, abnormal uterine bleeding and in combination with ERT (estrogen replacement therapy) to prevent estrogen from thickening and abnormal growth of the lining of the uterus. Medroxyprogesterone is also given to people including men suffering from sleep apnea to stimulate breathing.

Side Effects Of Medroxyprogesterone:

Common Medroxyprogesterone side effects include abdominal pain, acne, blood clot in a vein, lungs, or brain, breakthrough bleeding, breast tenderness, and increase in blood pressure. Other Medroxyprogesterone side effects may include depression, dry mouth, insomnia, headache, rash, itching, spotting, loss of appetite, fatigue, nausea, gain or loss of body hair and water retention. Medroxyprogesterone may cause dizziness. Do not drive a car or operate machinery until you know how Medroxyprogesterone affects you. Medroxyprogesterone may also increase sensitivity to the sun.

Medroxyprogesterone Caution:

Medroxyprogesterone should not be used during the first 4 months of pregnancy; as this could result in birth defects.
Avoid using Medroxyprogesterone if you are allergic or sensitive to any progestin.

Avoid using Medroxyprogesterone if you have a history of asthma, blood clot, depression, diabetes, epilepsy, high cholesterol, stroke, kidney or liver disease, varicose veins, heart problems, breast cancer, genital cancer, osteoporosis, undiagnosed vaginal bleeding or miscarriage.

Medroxyprogesterone Interaction:

Check with your doctor before combining Medroxyprogesterone with the following

• Aminoglutethimide
  
• Carbamazepine
  
• Phenobarbital
  
• Phenytoin
  
• Rifabutin
  
• Rifampin

Medroxyprogesterone And Pregnancy:

Avoid using Medroxyprogesterone during pregnancy. It may cause birth defects especially during the first 4 months of pregnancy.

Medroxyprogesterone appears in breast milk. If you are nursing switch to bottle-feed while taking Medroxyprogesterone.

Doses:

Dosage will depend on the medical condition being treated.
If Medroxyprogesterone upsets your stomach, take it with food.

Medroxyprogesterone overdose symptoms may include enhanced side effects. If you suspect an overdose seek medical help right away.If you miss a dose of Medroxyprogesterone, take it as soon as you can. However, if it is just about time for your next dose, skip the one you forgot and go on with your regular schedule. Never take a double dose of Medroxyprogesterone.